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Blood test that detects 50 different cancer types to roll out in US this year

A new blood test that could change the way cancer is detected and diagnosed is soon to become available in the U.S. The Galleri blood test, developed by GRAIL, can detect 50 types of cancer using only a blood test Mayo Clinic plans to make it available at multiple locations by the end of the year, and it has received approval for use in New York, according to Mailonline

The test requires two vials of blood that are sent to a laboratory and return results within 10 days Experts believe it can be a ‘game changer’ and help people detect their cancer early on, increasing their chance of survival The Galleri blood test was developed by GRAIL, a San Francisco, California-based biotechnology company.

 

The test is expected to be able to detect 50 different types of cancer via a blood test such as pancreatic, ovarian and esophageal. Its rollout would be ‘game changer’, one expert says, and it could potentially save millions of lives through early cancer diagnoses.

 

The test only requires two vials of blood, and a person will get results back in around ten days (file “If cancers can be detected early, we can dramatically improve patient outcomes,” Dr Julia Feygin, senior medical science liaison at GRAIL told WCCO in Minneapolis, Minnesota. Feygin’s father died of pancreatic cancer at the young age of 40 despite having no known risk factors.

 

She told WCCO that his story is why she wanted to work on this type of project. Many cancers are hard to screen for, and people may not even know they have it until it has developed to the point where they have a decreased likelihood to survive.

The Galleri cancer test works by screening the blood for abnormalities that could indicate cancer. Its developers say the test can detect over 50 types of cancer, and pinpoint where they are in the body.

 

Those taking part in the trials will be asked to give three samples of blood over the course of three years- each being around one and a half tablespoons (about 20 mL) of blood, just like a normal blood test. These are sent to a laboratory where scientists screen the sample for DNA with abnormal chemical changes.

 

It works by looking for chemical changes in fragments of genetic code – cell-free DNA (cfDNA) – that leak from tumors into the bloodstream. Some cancer tumors are known to shed DNA into the blood a long time before a person would start experiencing symptoms. Galleri says it takes around 10 days to turn around a test. They add that their test should be used in conjunction with normal screening programs. Scientists found in clinical trials that the test detected cancer correctly in 51.5 per cent of cases.

 

The trial involved 2,823 people who had cancer, and 1,254 people who did not. The Galleri test requires two tubes of a patient’s blood and, once it is sent back to a laboratory, it can take around 10 days for a person to get their results back.

 

“We can find and sequence these tiny bits of tumor derived DNA in the blood and based on the patterns we see we can reveal if there is a signal for cancer present,” Feygin said. “We can predict with very high accuracy where in the body this cancer signal is coming from.”

The Galleri test showed promise in clinical trials. A study conducted by the Mayo Clinic that included 6,600 participants found 29 people with a cancer case they previously did not know about. The test was found to only have a one per cent false-positivity rate. Some medical professionals are excited by the prospects of this test hitting the market in the near future.

 

“In the year 2021 this is so far beyond anything else we’ve been able to do. This is a gamechanger,’ Dr Greg Plotnikoff, a Minneapolis-based medical director, told WCCO. “If we can catch things earlier, we have a chance then to make a significant difference.”

 

He has prescribed the test to patients and family members who are at-risk ahead of Food and Drug Administration (FDA) approval, and even screened himself already. GRAIL is seeking approval from the FDA for the test, though a person can still ask their doctor to prescribe it to them in the meanwhile

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